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{ "pk": 28989, "title": "The role of AMPA receptor exchange in systems memory reconsolidation: Acomputational model", "subtitle": null, "abstract": "In the mammalian brain, a newly acquired memory depends on the hippocampus for maintenance and recall, but over timethe neocortex takes over these functions, rendering the memory hippocampus-independent. The process responsible forthis transformation is called systems memory consolidation. Interestingly, retrieval of a well-consolidated memory cantrigger a temporary return to a hippocampus-dependent state, a phenomenon known as systems memory reconsolidation.The neural mechanisms underlying systems memory consolidation and reconsolidation are not well understood. Here,we propose a neural model based on well-documented mechanisms of synaptic plasticity and stability and describe acomputational implementation that demonstrates the models ability to account for a range of findings from the systemsconsolidation and reconsolidation literature. Based on the computational model, we derive a number of predictions andsuggest experiments that may put them to the test.", "language": "eng", "license": { "name": "", "short_name": "", "text": null, "url": "" }, "keywords": [], "section": "Poster Presentations with Abstracts", "is_remote": true, "remote_url": "https://escholarship.org/uc/item/00s7m48t", "frozenauthors": [ { "first_name": "Peter", "middle_name": "", "last_name": "Helfer", "name_suffix": "", "institution": "McGill University", "department": "" }, { "first_name": "Thomas", "middle_name": "", "last_name": "Shultz", "name_suffix": "", "institution": "McGill University", "department": "" } ], "date_submitted": null, "date_accepted": null, "date_published": "2019-01-01T18:00:00Z", "render_galley": null, "galleys": [ { "label": "PDF", "type": "pdf", "path": "https://journalpub.escholarship.org/cognitivesciencesociety/article/28989/galley/18860/download/" } ] }