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{
    "pk": 49324,
    "title": "Algorithmic representations in the human brain that underlie schema generalisation",
    "subtitle": null,
    "abstract": "The human brain represents structure in the external world as \"cognitive maps\". However, it remains unknown how it represents structure in one's own behaviour. Recent findings show rodent medial-prefrontal cortex (mPFC) does this with a structure-sensitive representation, where all future actions are represented simultaneously. Here, using 7T fMRI, we test for this representation and its properties in humans. Using RSA and a computational model, we show this representation in mPFC and orbitofrontal cortex, while entorhinal and orbitofrontal cortices contain a pure abstraction of task structure. Preceding the future actions representation, action plans are ‘loaded' to mPFC once subjects were given all action-relevant information, suggestively through replay. iEEG data of patients solving the same task shows that sharp-wave ripple rate is increased during this planning time. Together, our findings suggest an algorithm of how human mPFC encodes future actions, and provide evidence for a replay-based mechanism of loading that representation.",
    "language": "eng",
    "license": {
        "name": "",
        "short_name": "",
        "text": null,
        "url": ""
    },
    "keywords": [
        {
            "word": "Cognitive Neuroscience; Action; Cognitive architectures; Decision making; Memory; Spatial cognition; Computational Modeling; Electroencephalography (EEG); fMRI"
        }
    ],
    "section": "Abstracts with Oral Presentation",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/8vz352cz",
    "frozenauthors": [
        {
            "first_name": "Svenja",
            "middle_name": "",
            "last_name": "KŸchenhoff",
            "name_suffix": "",
            "institution": "University of Oxford",
            "department": ""
        },
        {
            "first_name": "Alon",
            "middle_name": "",
            "last_name": "Baram",
            "name_suffix": "",
            "institution": "University of Oxford",
            "department": ""
        },
        {
            "first_name": "Mohamady",
            "middle_name": "",
            "last_name": "El-Gaby",
            "name_suffix": "",
            "institution": "University of Oxford",
            "department": ""
        },
        {
            "first_name": "Mathias",
            "middle_name": "",
            "last_name": "SablŽ-Meyer",
            "name_suffix": "",
            "institution": "University College London",
            "department": ""
        },
        {
            "first_name": "Adam",
            "middle_name": "",
            "last_name": "Harris",
            "name_suffix": "",
            "institution": "University of Oxford",
            "department": ""
        },
        {
            "first_name": "Jacob",
            "middle_name": "",
            "last_name": "Bakermans",
            "name_suffix": "",
            "institution": "Geneva University Neurocenter",
            "department": ""
        },
        {
            "first_name": "Shraddha",
            "middle_name": "",
            "last_name": "Shah",
            "name_suffix": "",
            "institution": "Baylor College of Medicine",
            "department": ""
        },
        {
            "first_name": "Eleonora",
            "middle_name": "",
            "last_name": "Bartoli",
            "name_suffix": "",
            "institution": "Baylor College of Medicine",
            "department": ""
        },
        {
            "first_name": "Andrew",
            "middle_name": "",
            "last_name": "Watrous",
            "name_suffix": "",
            "institution": "Baylor College of Medicine",
            "department": ""
        },
        {
            "first_name": "Adrish",
            "middle_name": "",
            "last_name": "Anand",
            "name_suffix": "",
            "institution": "Baylor College of Medicine",
            "department": ""
        },
        {
            "first_name": "Thomas",
            "middle_name": "",
            "last_name": "Donoghue",
            "name_suffix": "",
            "institution": "Columbia University",
            "department": ""
        },
        {
            "first_name": "Sandra",
            "middle_name": "",
            "last_name": "Maesta-Pereira",
            "name_suffix": "",
            "institution": "Columbia University",
            "department": ""
        },
        {
            "first_name": "Uros",
            "middle_name": "",
            "last_name": "Topalovic",
            "name_suffix": "",
            "institution": "University of California",
            "department": ""
        },
        {
            "first_name": "John",
            "middle_name": "",
            "last_name": "Sakon",
            "name_suffix": "",
            "institution": "University of California",
            "department": ""
        },
        {
            "first_name": "Elliot",
            "middle_name": "H",
            "last_name": "Smith",
            "name_suffix": "",
            "institution": "University of Utah",
            "department": ""
        }
    ],
    "date_submitted": null,
    "date_accepted": null,
    "date_published": "2025-01-02T00:00:00+06:00",
    "render_galley": null,
    "galleys": [
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            "label": "PDF",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/cognitivesciencesociety/article/49324/galley/37285/download/"
        }
    ]
}