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{
    "pk": 50474,
    "title": "Age-related changes in cognitive flexibility: fMRI meta-analysis",
    "subtitle": null,
    "abstract": "<p>To examine neural mechanisms underlying cognitive flexibility changes with ageing, we synthesized findings from 87 fMRI studies, comprising 120 experiments with 2308 adult participants distributed across young, middle-age, and older groups. Our meta-analysis was focused on rule-retrieval and rule-discovery processes, assessed with Task-Switching Paradigm and Wisconsin Card Sorting Test, respectively. Activation Likelihood Estimation analyses revealed age-related decreases in brain activation related to general switching ability, particularly in posterior regions, alongside an anterior shift in older adults, consistent with the Posterior-Anterior Shift in Aging (PASA) model. Rule-retrieval tasks consistently engaged left-lateralized frontoparietal regions across all age groups, with middle-age adults additionally recruiting the right cerebellum and medial-frontal gyrus. For rule-discovery tasks, age-related decline was observed in bilateral frontoparietal regions, while older adults also showed unique activation in the left inferior-frontal gyrus. These findings highlight differential ageing trajectories for rule retrieval and rule discovery, potentially reflecting compensatory neural mechanisms and dedifferentiation processes.</p>",
    "language": "eng",
    "license": {
        "name": "",
        "short_name": "",
        "text": null,
        "url": ""
    },
    "keywords": [
        {
            "word": "Cognitive Neuroscience; Neuroscience; Psychology; Cognitive development; Development; Other; fMRI"
        }
    ],
    "section": "Member Abstracts with Poster Presentation",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/0zn5r8z3",
    "frozenauthors": [
        {
            "first_name": "Zhanna",
            "middle_name": "",
            "last_name": "Chuikova",
            "name_suffix": "",
            "institution": "HSE University",
            "department": ""
        },
        {
            "first_name": "Andrei",
            "middle_name": "",
            "last_name": "Faber",
            "name_suffix": "",
            "institution": "HSE University",
            "department": ""
        },
        {
            "first_name": "Andrei",
            "middle_name": "",
            "last_name": "Filatov",
            "name_suffix": "",
            "institution": "HSE University",
            "department": ""
        },
        {
            "first_name": "Andriy",
            "middle_name": "",
            "last_name": "Myachykov",
            "name_suffix": "",
            "institution": "University of Macau",
            "department": ""
        },
        {
            "first_name": "Yury",
            "middle_name": "",
            "last_name": "Shtyrov",
            "name_suffix": "",
            "institution": "Aarhus University",
            "department": ""
        },
        {
            "first_name": "Marie",
            "middle_name": "",
            "last_name": "Arsalidou",
            "name_suffix": "",
            "institution": "York University",
            "department": ""
        }
    ],
    "date_submitted": null,
    "date_accepted": null,
    "date_published": "2025-01-01T18:00:00Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "PDF",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/cognitivesciencesociety/article/50474/galley/38436/download/"
        }
    ]
}